Biophysics Coursework of ?Biophysics? includes biophysics of ...

Biophysics Coursework of "Biophysics" includes biophysics of human and elements of
medical physics. In general biophysics is an interdisciplinary branch of
science which develops at the border of physics, chemistry, biology and
medical sciences. It employs physical methods and techniques to study
phenomena taking place in living organisms at all levels of their
organization, from the micro to the macro scale, from molecules to cells
and whole organisms. Medical physics means application of physical
phenomena and physical methods and techniques (e.g. ultrasounds, light,
laser, ionizing radiation, nuclear resonance) in medical diagnosis and
therapy. Teachers: Lectures : dr hab. Stefan Kruszewski, prof. UMK dr Maciej Bosek dr Ma?gorzata Pyskir dr Blanka Ziomkowska Contact: dr Blanka Ziomkowska blanka@cm.umk.pl
Syllabus I. Department of Biophysics
II. Head of the Department: Dr hab. Bronis?aw Grzegorzewski, prof UMK
III. Faculty of Medicine, first year
IV. Programme Tutor: dr hab. Stefan Kruszewski, prof UMK
V. Lectures and tutorials
VI. Assessment: Examination, 7 ECTS points
VII. Subject Hours: lectures 30h , exercises 45h, total 75h
VIII. Aims of the Subject:
Providing with fundamental laws and research methods of physic in order to
describe the features of biological systems and phenomena occurring in
them.
IX. Lecture topics:
1. Introduction. What is Biophysics. Structure of matter. Fundamental
interactions.
2. Mathematical description of dependences between physical quantity.
Derivative, integral and differential equations.
3. Laws of thermodynamics, thermodynamic function of state, chemical
potential. Diffusion, osmosis. Nonequilibrium thermodynamics,
transport. Open systems. Electrochemical potential. Electrode
potential, diffusion potential, membrane potential. Elements of
bioenergetics.
4. Biophysics of cell. Cell membrane, transmembrane transport. Resting
potential. Nervous tissue, action potential. Muscular tissue.
5. Vibration, acoustic wave. Reflection coefficient. Sound features,
sound intensity level, loudness level. Auditory system, speech organs.
6. Viscosity, fluid flow. Viscosity of blood, vessel resistance.
Circulatory system.
7. Optics. Electromagnetic wave. Optical fiber. Optical systems.
Microscopic technique. Resolving power. Optical layout of the eye,
defects of vision. Vision process. Illumination units. Lasers in
medicine.
8. Electricity and magnetism. Maxwell equations. Electric dipole. Cardiac
pacemaker. Electrocardiography. Einthoven lead.
9. Electric current. RC, RL and RLC circuits. Electric features of cells
and tissues.
10. The influence of physical factors on organism. Mechanical, thermal,
electric and magnetic factors, ionic radiation.
11. Physical methods in medical diagnostics.
X. Tutorials Students perform the assigned practice, which were chosen from the
following list:
1. Transmembrane transport: diffusion, osmosis
2. The Lambert-Beer law
3. Fluid flow analysis
4. Viscosity
5. Electric model of cell
6. Spectral analysis of sound
7. Audiometry
8. Microwave analysis
9. Magnetic fields analysis
10. Elements of biomechanics
11. Physical basis of electrocardiography
12. Microscope
13. Optical basis of correction of vision defects
14. Absorption of gamma radiation
XI. Bibliography:
General reading: 1) Elements of medical biophysics, edited by Leszek Kubisz, Poznan
University of Medical Sciences, Pozna? 2007
2) Laboratory Exercises in Biophysics, edited by Marek Tuliszka, Poznan
University of Medical Sciences, Pozna? 2008
3) Physics in Biology and Medicine, P.Daviodovits, Harcourt Academic
Press, 2001
4) Biophysics, R.Glaser, Springer-Verlag 2005
Supplementary reading: 1) Physics of the Body, Cameron John R., Skofronick James G., and Grant
Roderick M., Medical Physics Publishing, Medisson, Wisconsin 1992
2) College Physics, Willson Jerry D., Buffa Anthony J., Prentice Hall,
4th Edition, 2000
3) An Introduction to Biophysics with Medical Orientation, L.Berkes, et
al., G.Ronto, I. Trajan (Eds.), Akademiai Kiado 1994
4) Physics for medicine & biology, R.K. Hobbie, Springer Verlag, 1997
5) Medical Physics and Biomedical Engineering, H. Brow, et al., IOP
Publishing
Rules and regulations Information about the course "Biophysics" program is realized in the first semester of first year. The
coursework of Biophysics includes 30 hours of lectures and 45 hours of
laboratory exercises. Laboratory exercises are realized in Student
Laboratory in Biophysics Department. The labs and lectures are prepared in
a week cycle. Students have to pass biophysical laboratory exercises i.e.
perform nine practical laboratory exercises and pass three test (after
performing each three practice exercises). Biophysics is ended with the
Final Exam in writing form. Exam covers the topics of lectures and
exercises. Obligatory textbook:
1. Elements of medical biophysics, edited by Leszek Kubisz, Poznan
University of Medical Sciences, Pozna? 2007 2. Laboratory Exercises in Biophysics, edited by Marek Tuliszka, Poznan
University of Medical Sciences, Pozna? 2008 3. Physics in Biology and Medicine, P.Daviodovits, Harcourt Academic Press,
2001 4. Biophysics, R.Glaser, Springer-Verlag 2005
Additional textbooks:
1. Physics of the Body, Cameron John R., Skofronick James G., and Grant
Roderick M., Medical Physics Publishing, Medisson, Wisconsin 1992 2. College Physics, Willson Jerry D., Buffa Anthony J., Prentice Hall, 4th
Edition, 2000 3. An Introduction to Biophysics with Medical Orientation, L.Berkes, et
al., G.Ronto, I. Trajan (Eds.), Akademiai Kiado 1994 4. Physics for medicine & biology, R.K. Hobbie, Springer Verlag, 1997 5. Medical Physics and Biomedical Engineering, H. Brow, et al., IOP
Publishing
REGULATIONS OF STUDENTS LABORATORY IN THE BIOPHYSICS DEPARTMENT I. The aims of the laboratory. The aim of the biophysics laboratory is to introduce students to the
commonly encountered measuring apparatus, development of a scientific
understanding of biological phenomena, logical observations and facts
recollection as well as the development of a critical view on the
outcomes of measurements.
Students realize above aims by individually conducting experiments.
II. The course of classes in the laboratory. 1. The experiments in the laboratory are performed according to the course
of study. 2. Classes are forerun with an introduction, during which regulations,
experiment assignment, methods of data collection and processing are
discussed. Safety training is carried out. 3. Experiments curriculum, theoretical knowledge requirements and
literature suggestions are on the board of announcements in the
department of biophysics. 4. A student is expected to realize 9 experiments, take a test and come up
with measurement results and write lab report. 5. Every experiment is realized by two students simultaneously. 6. To every experiment a student has to prepare theoretical knowledge.
Preparation will be tested by the tutor during the experiment. Attention! In case of unfamiliarity with the material needed for safe and
secure performance of the given experiment, the tutor has the right to
abort the undertaken experiment. 7. The student must complete and pass each exercise performed. The complete
passing of an experiment is determined by the tutor on the bases of
tests, work during class and compiled results.
In the case of wrong experiment or errors in report, tutor inform
about the need of repeat of experiment or its part or correction of lab
report. Every correction has to be realized in the laboratory. It is not
allowed to take experimental cards to home! 8. A complete experiment in the lab covers:
Entrance to the lab: a student is obliged to show his tutor a written
compilation of the theoretical part and to pick up his experimental card;
Carrying out the experiment i.e.
- a thorough familiarization with the instructions to the exercise
undertaken.
- turning on the measuring devices, taking measurements and filling
out a experimental card. Results should be written in either pen or
fountain pen (not in pencil!)
Preparing the elaboration of the results on an experimental card.
Finishing of work in the laboratory includes: - Tidying up of workplace. - Returning filled experimental card together with written
compillation of the theory of performed exercice. If student doesn't manage to prepare the lab report during classes,
he should report it and return it unfinished. It can be finished in the
appointed week. Student can also finish them during next classes in the
laboratory. 9. Student can only pass and conduct experiments according to his group's
schedule. 10. The longest acceptable late-coming is 15 minutes. After this time,
student cannot participate in classes. 11. Experiment conducted not individually is not treated as completed. 12. All the absences must be excused at the group's tutor. Tutor sets a new
date for conducting particular experiment. 13. Conditions of getting pass the laboratory work are the following:
passing all the tests, carrying out indicated experiments and elaborating
their results. III. Order regulations. 1. All operations during setting the devices should be conducted
individually